Firefighters have told local media they had been forced back from the wreckage on several occasions due to ‘high intensity’ explosions.
A Mississippi State Trooper said the aircraft was ‘loaded with ammunition’.
“There’s a lot of ammo in the plane.”
The aircraft is believed to have exploded mid-air as wreckage has been found on both sides of the nearby Highway 82
The aircraft was reportedly last detected by air traffic control at a height of 20,000 feet (6km)
Sheriff Ricky Banks earlier told media his officers were searching for bodies and that no survivors were expected.
The US Marine Corps Twitter account posted that “A USMC KC-130 mishap occurred the evening of July 10. Further information will be released as available.”